The long road to TRAIL therapy: a TRAILshort detour

The Long Road to Eradicate Rinderpest

The VASP Road to NAFLD: A Macrophage Detour

Nonalcoholic fatty liver disease (NAFLD), a common clinical disorder, is increasing largely due to increasing consumption of diets high in fructose and fat (1–3). Indeed, NAFLD has been reported to be present in up to 30% of the U.S. population (3), closely mirroring the prevalence of obesity. Its presence carries an increased risk for type 2 diabetes, endstage liver disease, and cardiovascular...

the long road to eradicate rinderpest

Integrated delivery networks: a detour on the road to integrated health care?

This paper reviews the rationales and evidence for horizontal and vertical integration involving hospitals. We find a disjunction between the integration rationales espoused by providers and those cited in the academic literature. We also generally find that integration fails to improve hospitals' economic performance. We offer seven lessons from hospitals' efforts to integrate and then suggest...

The NO TRAIL to YES TRAIL in cancer therapy (review).

Treatment of cancer patients with conventional therapies (chemotherapy, hormonal therapy, immunotherapy and radiation) respond initially well and experience prolonged tumor-free survival. However, in many patients tumor recurrences and relapses occur and such tumors exhibit the resistant phenotype i.e. cross-resistance to various cytotoxic and apoptotic agents. Therefore, new therapeutic strate...